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Directions. Read the Patient Information Leaflet provided by your pharmacist before you start using sorafenib. Take this medication by mouth on an empty stomach (at least 1 hour before or 2 hours after a meal) as directed by your doctor, usually twice a day. Do not chew or crush the tablets. Swallow tablets whole with a full glass of water.
Precautions. Nexavar can cause heart problems. Stop taking this medicine and call your doctor at once if you have chest pain and severe dizziness, fainting, sweating, or feeling short of breath. Nexavar can also cause severe bleeding. Call your doctor if you have blood in your urine or stools, abnormal vaginal bleeding, severe stomach pain, coughing up blood, or any bleeding that will not stop. Do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose. To lower the chance of getting cut, bruised or injured, use caution with sharp objects like safety razors and nail cutters, and avoid activities such as contact sports. Women who are pregnant must not take this medication as it can be absorbed through the skin and lungs and may harm an unborn baby.
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Possible side effect. The most common side effects are acne, dry skin, nausea, diarrhea, patchy hair loss/thinning, loss of appetite, dry mouth, hoarseness, or tiredness may occur. Notify your doctor if these effects persist or worsen. Serious side aeffects are bone/muscle pain, depression, easy bruising or bleeding, headache, tongue/mouth sores or pain, numbness/tingling of the hands/feet, shortness of breath, swollen hands/ankles/feet, signs of liver problems such as stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine. Check your blood pressure regularly as this medication may raise it. This medication can affect how your thyroid works. Tell your doctor right away if you have signs of an underactive thyroid such as weight gain, cold intolerance, slow heartbeat, constipation, or unusual tiredness or signs of an overactive thyroid such as mental/mood changes, heat intolerance, fast/pounding/irregular heartbeat or unusual weight loss. Contact your doctor right away if you notice skin problems (such as rash, blisters, redness, swelling, pain), especially on the palms of your hands or the soles of your feet.