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Spironolactone also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. This medication is also used to treat or prevent hypokalemia (low potassium levels in the blood).
BRAND NAME: Aldactone. USES: Aldactone removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease. It also can be used in combination with other drugs to treat elevated blood pressure, and for treating diuretic-induced low potassium (hypokalemia).
Spironolactone works by blocking the actions of a hormone in the body called aldosterone. This hormone is produced by glands found above the kidneys called the adrenal glands. Aldosterone acts in the kidneys, where it is involved in controlling the balance of salt and water in the body.
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According to the low effective arterial volume and the extrarenal loss of sodium, aldosterone secretion increased. ... However, during episodes of intestinal loss of sodium the spironolactone-induced impairment of aldosterone-mediated resorption of sodium can cause a life-threatening hyponatremia.
Spironolactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spironolactone is used to diagnose or treat a condition in which you have too much aldosterone in your body.